How are codons that span introns represented in sequence listings?

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Source: FAQ (MPEP-Based) BlueIron Update: 2024-09-30 10 Rules 5 Related FAQs This page is an FAQ based on guidance from the Manual of Patent Examining Procedure. It is provided as guidance, with links to the ground truth sources. This is information only: it is not legal advice. The MPEP addresses the representation of codons that span introns in 37 CFR 1.822(c)(3) . Specifically, it states: “In those situations, the ‘amino acid symbol shall be listed below the portion of the codon containing two nucleotides.'” This requirement clarifies how to represent an amino acid corresponding to a codon that spans an intron. It ensures that the amino acid is aligned with the majority of its corresponding codon, providing a clear and consistent representation in the sequence listing. Related Rules from the Manual of Patent Examining Procedure 10 rules Collapse Amino Acids Must Be Listed Below Coding Codons MPEP 2423.02 Amino Acid Must Be Listed for Codon Spanning Intron MPEP 2423.02 Amino Acids Must Be Listed Below Codon Portions MPEP 2423.02 Required Amino Acid Below Two Nucleotides in Codon Spanning Intron MPEP 2423 Required Amino Acids Must Be Listed Below Corresponding Codons MPEP 2423 Required Amino Acid Symbol for Intron-Crossing Codons Required MPEP 2423.02 Nucleotide Sequence Must Be Listed in Codons or Bases MPEP 2423 Required Coding Regions Not Required MPEP 2423.02 Recommended Coding Parts Must Be Listed as Triplets MPEP 2423 Required Amino Acid Sequence Must Be Set Forth Separately MPEP 2423.02 Required Other Related FAQs 5 FAQs Collapse How should coding regions be depicted in patent applications? Is it mandatory to depict coding regions in patent applications? When must amino acid sequences be set forth separately in a patent application? How should ambiguity symbols be used in nucleotide sequences? What is the correct format for presenting amino acid symbols in a Sequence Listing?