How are modified amino acids represented in a sequence listing?
According to MPEP 2412.05(d), modified amino acids should be represented as follows:
- Represent as the corresponding unmodified amino acid when possible
- Use ‘X’ for modified amino acids that cannot be represented by other symbols
- Provide further description in a feature table
The MPEP states, “WIPO Standard ST.26, paragraph 29, specifies that modified amino acids, including D-amino acids, should be represented in the sequence as the corresponding unmodified amino acids whenever possible. Any modified amino acid in a sequence that cannot otherwise be represented by any other symbol in Table 3: List of Amino Acids Symbols (reproduced in MPEP § 2412.03(a)), i.e., an “other” amino acid, must be represented by “X”.” Additionally, modified amino acids must be further described in a feature table using appropriate feature keys and qualifiers.
To learn more:
Topics:
MPEP 2400 - Biotechnology,
MPEP 2412.05(D) - Representation And Symbols Of Amino Acid Sequence Data,
Patent Law,
Patent Procedure