Why are drawing figures recommended for certain sequence representations?

Drawing figures are recommended for certain sequence representations because they can effectively illustrate important characteristics that may not be adequately conveyed in a standard sequence listing. The MPEP 2422.02 provides several reasons for this:

1. Double-stranded nucleotides: “The representation of double stranded nucleotides is not permitted in the ‘Sequence Listing’.”
2. Specific nucleotide features: “Many significant nucleotide features, such as ‘sticky ends’ and the like, may only be shown effectively by reference to a drawing figure.”
3. Sequence similarity: “The similarity or homology between/among sequences may only be depicted in an effective manner in a drawing figure.”
4. Protein structural features: “Drawing figures are recommended for use with amino acid sequences to depict structural features of the corresponding protein, such as epitopes and interaction domains.”

These visual representations can provide crucial information about the sequences that complement the standardized sequence listing. However, it’s important to note that when a sequence is presented in a drawing, it must still be included in the “Sequence Listing” if it falls within the definition set forth in 37 CFR 1.821(a), and a sequence identifier must be used.

To learn more:

• drawing figures
• sequence representation
• double-stranded nucleotides
• protein structural features
• sequence similarity