What are the options for submitting a large “Sequence Listing” that exceeds 100 MB?

This page is an FAQ based on guidance from the Manual of Patent Examining Procedure. It is provided as guidance, with links to the ground truth sources. This is information only: it is not legal advice.

For “Sequence Listings” larger than 100 MB, MPEP 2425 provides the following guidance:

• The “Sequence Listing” may be submitted on read-only optical disc(s) in compliance with 37 CFR 1.52(e)
• A file that is not compressed must be contained on a single read-only optical disc
• The file may be compressed using WinZip®, 7-Zip, or Unix®/Linux® Zip
• A compressed file must not be self-extracting
• A compressed ASCII plain text file that does not fit on a single read-only optical disc may be split into multiple file parts

As stated in 37 CFR 1.824(b)(2), “On a read-only optical disc(s), in compliance with § 1.52(e)“. This provision allows for the submission of large Sequence Listings that cannot be filed electronically due to size limitations.