How should unknown amino acids be represented in sequence listings?
How should unknown amino acids be represented in sequence listings? The MPEP 2412.05 provides specific guidance on representing unknown amino acids in sequence listings: “The symbol “Xaa” must be used to represent an unknown or other amino acid.” This means that whenever an amino acid in a sequence is unknown or cannot be confidently identified,…
Read MoreHow should ambiguity symbols be used in amino acid sequences?
The use of ambiguity symbols in amino acid sequences is addressed in MPEP 2412.05(d). Here are the key points: Ambiguity symbols are used when an amino acid in a sequence is not clearly identified. The MPEP states: “The symbol “Xaa” or “X” should be used for an unknown or other amino acid.“ When “X” is…
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