Can references from non-analogous art ever be used in obviousness rejections?

While it is generally preferred to rely on analogous art for obviousness rejections, there are circumstances where references from non-analogous art can be used. The MPEP 2141.01(a) provides guidance on this: “The examiner must determine what is ‘analogous prior art’ for the purpose of analyzing the obviousness of the subject matter at issue. […] However,…

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