What symbols are used for termination codons in amino acid sequences?

This page is an FAQ based on guidance from the Manual of Patent Examining Procedure. It is provided as guidance, with links to the ground truth sources. This is information only: it is not legal advice.

According to MPEP 2412.05(d), termination codons in amino acid sequences are represented by specific symbols:

• An asterisk (*) is used to represent termination codons in amino acid sequences.
• The MPEP states: “The symbols set forth in Table 3 of Appendix G should be used to represent amino acids. Termination codons should be shown as an asterisk (*).“
• This symbol is universally recognized in sequence listings and helps distinguish the end of a coding sequence.

It’s important to use this standardized symbol to ensure clarity and consistency in patent applications involving amino acid sequences.