How should modified residues be represented in a Sequence Listing XML?

Representing modified residues correctly in a Sequence Listing XML is crucial for accurately describing non-standard amino acids or nucleotides. According to MPEP 2413.01(g):

“For the ‘note’ qualifier, where the variant residue is a modified residue not set forth in Table 2, the complete unabbreviated name of the modified residue must be provided as the qualifier value. Modified residues must be further described in a FEATURE TABLE as described above at subsection (I).”

Key points for representing modified residues:

• Use the appropriate symbols from Tables 1 to 3 where possible.
• For modified residues not in these tables, provide the full, unabbreviated name in the “note” qualifier.
• Include additional description in the feature table for clarity.

Proper representation of modified residues ensures that all relevant structural information is accurately captured in the patent application.

To learn more:

• modified residues
• Sequence Listing XML
• WIPO Standard ST.26
• patent application
• feature table