How should modified and unusual amino acids be represented in a sequence listing?
The MPEP 2423.01 provides specific guidance on representing modified and unusual amino acids in a sequence listing: “Modified and unusual amino acids must be represented as the corresponding unmodified amino acids in the sequence itself but may be further described in the feature section of the sequence listing.” This means that: In the main sequence,…
Read MoreWhat are the accepted symbols for modified nucleotides in sequence listings?
What are the accepted symbols for modified nucleotides in sequence listings? According to MPEP 2412.05, modified nucleotides can be represented in sequence listings using specific symbols. The MPEP states: “Modified nucleotides may be represented in the sequences as described in paragraph 3 of this section with the symbol “n,” and must be further described in…
Read MoreHow are amino acids with ambiguous positions represented in sequence listings?
How are amino acids with ambiguous positions represented in sequence listings? The MPEP 2412.05 provides guidance on representing amino acids with ambiguous positions: “Where an amino acid can be one of two or more alternatives at a given position in a sequence, the preferred amino acids should be shown in the sequence and the alternatives…
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