MPEP § 2435 — Publishing of Patents and Patent Application Publications with a Lengthy “Sequence Listing” (Annotated Rules)

§2435 Publishing of Patents and Patent Application Publications with a Lengthy “Sequence Listing”

USPTO MPEP version: BlueIron's Update: 2025-12-31

This page consolidates and annotates all enforceable requirements under MPEP § 2435, including statutory authority, regulatory rules, examiner guidance, and practice notes. It is provided as guidance, with links to the ground truth sources. This is information only, it is not legal advice.

Publishing of Patents and Patent Application Publications with a Lengthy “Sequence Listing”

This section addresses Publishing of Patents and Patent Application Publications with a Lengthy “Sequence Listing”. Primary authority: 35 U.S.C. 122(b) and 37 CFR 1.19(b)(3). Contains: 3 permissions and 4 other statements.

Key Rules

Topic

Sequence Listing Format

7 rules
StatutoryInformativeAlways
[mpep-2435-dcdf591a7e37d97abf4509ae]
Requirement for Lengthy Sequence Listing
Note:
The patent must include a lengthy 'Sequence Listing' section, which can be accessed electronically from the USPTO website.

The patent contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO web site (https://seqdata.uspto.gov). An electronic copy of the “Sequence Listing” will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Jump to MPEP Source · 37 CFR 1.19(b)(3)Sequence Listing FormatSequence Listing RequirementsDocument Supply Fees
StatutoryInformativeAlways
[mpep-2435-45e758f25677a3b80b414eac]
Sequence Listing Available Electronically from USPTO
Note:
A copy of the Sequence Listing is available electronically on the USPTO website and can also be obtained upon request for a fee.

The patent contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO web site (https://seqdata.uspto.gov). An electronic copy of the “Sequence Listing” will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Jump to MPEP Source · 37 CFR 1.19(b)(3)Sequence Listing FormatSequence Listing RequirementsDocument Supply Fees
StatutoryInformativeAlways
[mpep-2435-78c3508871a3f00068959264]
Requirement for Lengthy Sequence Listing
Note:
The patent application must include a lengthy ‘Sequence Listing’ section, which can be accessed electronically from the USPTO website or upon request.

The patent application contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO web site (https://seqdata.uspto.gov). An electronic copy of the “Sequence Listing” will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Jump to MPEP Source · 37 CFR 1.19(b)(3)Sequence Listing FormatSequence Listing RequirementsDocument Supply Fees
StatutoryInformativeAlways
[mpep-2435-00af07436df98854e58b64b4]
Sequence Listing Available Electronically from USPTO
Note:
A copy of the Sequence Listing is available electronically on the USPTO website and can be obtained upon request with a fee.

The patent application contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO web site (https://seqdata.uspto.gov). An electronic copy of the “Sequence Listing” will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Jump to MPEP Source · 37 CFR 1.19(b)(3)Sequence Listing FormatSequence Listing RequirementsDocument Supply Fees
StatutoryPermittedAlways
[mpep-2435-c0dbfcd9986ad6c936afa14b]
Sequence Data Accessible from NCBI or Vendor
Note:
Patent sequence data can be accessed through the National Center for Biotechnology Information (NCBI) or a commercial vendor.

Sequence data may also be accessed in a more readily searchable manner from the National Center for Biotechnology Information (NCBI) at www.ncbi.nlm.nih.gov or from a commercial vendor. The USPTO forwards a copy of the sequence data to NCBI when a patent including a “Sequence Listing” is granted, and when an application containing a sequence is published pursuant to 35 U.S.C. 122(b). If NCBI elects to include the sequence data in one of its databases, NCBI indexes the sequence data according to patent or patent application publication number. There is currently no fee for the public to use the NCBI site.

Jump to MPEP SourceSequence Listing FormatSequence Listing RequirementsFees for Third Party Access
StatutoryInformativeAlways
[mpep-2435-dd4f44963e6ffd28521174f8]
USPTO Forwards Sequence Data to NCBI Upon Grant or Publication
Note:
The USPTO sends a copy of sequence data to NCBI when a patent with a 'Sequence Listing' is granted or an application containing sequences is published.

Sequence data may also be accessed in a more readily searchable manner from the National Center for Biotechnology Information (NCBI) at www.ncbi.nlm.nih.gov or from a commercial vendor. The USPTO forwards a copy of the sequence data to NCBI when a patent including a “Sequence Listing” is granted, and when an application containing a sequence is published pursuant to 35 U.S.C. 122(b). If NCBI elects to include the sequence data in one of its databases, NCBI indexes the sequence data according to patent or patent application publication number. There is currently no fee for the public to use the NCBI site.

Jump to MPEP SourceSequence Listing FormatAccess to Patent Application Files (MPEP 101-106)Sequence Listing Requirements
StatutoryInformativeAlways
[mpep-2435-9d33111dcb62bdb86a86ec69]
NCBI Must Index Sequence Data by Publication Number
Note:
If NCBI chooses to include sequence data in its databases, it must index the data using the patent or patent application publication number.

Sequence data may also be accessed in a more readily searchable manner from the National Center for Biotechnology Information (NCBI) at www.ncbi.nlm.nih.gov or from a commercial vendor. The USPTO forwards a copy of the sequence data to NCBI when a patent including a “Sequence Listing” is granted, and when an application containing a sequence is published pursuant to 35 U.S.C. 122(b). If NCBI elects to include the sequence data in one of its databases, NCBI indexes the sequence data according to patent or patent application publication number. There is currently no fee for the public to use the NCBI site.

Jump to MPEP SourceSequence Listing FormatSequence Listing RequirementsFees for Third Party Access
Topic

Fees for Third Party Access

2 rules
StatutoryPermittedAlways
[mpep-2435-39e97b0e1758b7113a6df51b]
Electronic Copies of Sequence Listings Available for Fee
Note:
Applicants and the public can obtain electronic copies of sequence listings through the Patent and Trademark Copy Fulfillment Branch for a fee.

Copies of U.S. patents and U.S. patent application publications are not provided in paper to applicants and are not placed in the application file. See MPEP § 707.05(a). If an applicant desires an electronic copy of a “Sequence Listing”, applicant may either download the “Sequence Listing” from the USPTO sequence homepage (https://seqdata.uspto.gov/) or specifically request and pay for the electronic copy through the Patent and Trademark Copy Fulfillment Branch of the Public Records Division. Both applicants and members of the general public can obtain an electronic copy of the “Sequence Listing” through the Patent and Trademark Copy Fulfillment Branch for a separate fee as set forth in 37 CFR 1.19(b)(3). See MPEP § 1730 for contact information for the Patent and Trademark Copy Fulfillment Branch.

Jump to MPEP Source · 37 CFR 1.19(b)(3)Fees for Third Party AccessThird Party Access to Files (MPEP 103, 1134.01)Document Supply Fees
StatutoryInformativeAlways
[mpep-2435-7bbb9eb8705c61f9b1048be9]
Public Can Use NCBI Free
Note:
The public can access sequence data on the NCBI site without paying any fees.

Sequence data may also be accessed in a more readily searchable manner from the National Center for Biotechnology Information (NCBI) at www.ncbi.nlm.nih.gov or from a commercial vendor. The USPTO forwards a copy of the sequence data to NCBI when a patent including a “Sequence Listing” is granted, and when an application containing a sequence is published pursuant to 35 U.S.C. 122(b). If NCBI elects to include the sequence data in one of its databases, NCBI indexes the sequence data according to patent or patent application publication number. There is currently no fee for the public to use the NCBI site.

Jump to MPEP SourceFees for Third Party AccessThird Party Access to Files (MPEP 103, 1134.01)Sequence Listing Format
Topic

Document Supply Fees

2 rules
StatutoryInformativeAlways
[mpep-2435-8194c753434db662d525c067]
Fee for Electronic Sequence Listing
Note:
Pay the fee set forth in 37 CFR 1.19(b)(3) to obtain an electronic copy of the Sequence Listing from the USPTO.

The patent contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO web site (https://seqdata.uspto.gov). An electronic copy of the “Sequence Listing” will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Jump to MPEP Source · 37 CFR 1.19(b)(3)Document Supply FeesMaintenance Fee AmountsSequence Listing Format
StatutoryInformativeAlways
[mpep-2435-4fcbddd5343adeefda7e6e81]
Fee for Electronic Sequence Listing
Note:
Pay the fee set forth in 37 CFR 1.19(b)(3) to obtain an electronic copy of the Sequence Listing from the USPTO.

The patent application contains a lengthy “Sequence Listing” section. A copy of the “Sequence Listing” is available in electronic form from the USPTO web site (https://seqdata.uspto.gov). An electronic copy of the “Sequence Listing” will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

Jump to MPEP Source · 37 CFR 1.19(b)(3)Document Supply FeesMaintenance Fee AmountsSequence Listing Format
Topic

Access to Patent Application Files (MPEP 101-106)

1 rules
StatutoryInformativeAlways
[mpep-2435-9c554b440efeb44adc4fbade]
Sequence Listing Not Provided In Paper
Note:
Applicants cannot receive paper copies of U.S. patents, patent application publications, or Sequence Listings; they must be obtained electronically.

Copies of U.S. patents and U.S. patent application publications are not provided in paper to applicants and are not placed in the application file. See MPEP § 707.05(a). If an applicant desires an electronic copy of a “Sequence Listing”, applicant may either download the “Sequence Listing” from the USPTO sequence homepage (https://seqdata.uspto.gov/) or specifically request and pay for the electronic copy through the Patent and Trademark Copy Fulfillment Branch of the Public Records Division. Both applicants and members of the general public can obtain an electronic copy of the “Sequence Listing” through the Patent and Trademark Copy Fulfillment Branch for a separate fee as set forth in 37 CFR 1.19(b)(3). See MPEP § 1730 for contact information for the Patent and Trademark Copy Fulfillment Branch.

Jump to MPEP Source · 37 CFR 1.19(b)(3)Access to Patent Application Files (MPEP 101-106)Fees for Third Party AccessThird Party Access to Files (MPEP 103, 1134.01)
Topic

Third Party Access to Files (MPEP 103, 1134.01)

1 rules
StatutoryPermittedAlways
[mpep-2435-1aa2ad2878119d9d3400303e]
How to Obtain Electronic Sequence Listing
Note:
Applicants can download the electronic Sequence Listing from the USPTO website or request a copy through the Patent and Trademark Copy Fulfillment Branch for a fee.

Copies of U.S. patents and U.S. patent application publications are not provided in paper to applicants and are not placed in the application file. See MPEP § 707.05(a). If an applicant desires an electronic copy of a “Sequence Listing”, applicant may either download the “Sequence Listing” from the USPTO sequence homepage (https://seqdata.uspto.gov/) or specifically request and pay for the electronic copy through the Patent and Trademark Copy Fulfillment Branch of the Public Records Division. Both applicants and members of the general public can obtain an electronic copy of the “Sequence Listing” through the Patent and Trademark Copy Fulfillment Branch for a separate fee as set forth in 37 CFR 1.19(b)(3). See MPEP § 1730 for contact information for the Patent and Trademark Copy Fulfillment Branch.

Jump to MPEP Source · 37 CFR 1.19(b)(3)Third Party Access to Files (MPEP 103, 1134.01)Sequence Listing FormatSequence Listing Requirements

Citations

Primary topicCitation
Fees for Third Party Access
Sequence Listing Format
35 U.S.C. § 122(b)
Access to Patent Application Files (MPEP 101-106)
Document Supply Fees
Fees for Third Party Access
Sequence Listing Format
Third Party Access to Files (MPEP 103, 1134.01)
37 CFR § 1.19(b)(3)
Access to Patent Application Files (MPEP 101-106)
Fees for Third Party Access
Third Party Access to Files (MPEP 103, 1134.01)
MPEP § 1730
Access to Patent Application Files (MPEP 101-106)
Fees for Third Party Access
Third Party Access to Files (MPEP 103, 1134.01)
MPEP § 707.05(a)

Source Text from USPTO’s MPEP

This is an exact copy of the MPEP from the USPTO. It is here for your reference to see the section in context.

BlueIron Last Updated: 2025-12-31