MPEP § 2414 — Notification of a Failure to Comply with Sequence Listing Requirements and Amendments Relating to “Sequence Listing XML” Files Under 37 CFR 1.835 (Annotated Rules)

§2414 Notification of a Failure to Comply with Sequence Listing Requirements and Amendments Relating to “Sequence Listing XML” Files Under 37 CFR 1.835

USPTO MPEP version: BlueIron's Update: 2025-12-31

This page consolidates and annotates all enforceable requirements under MPEP § 2414, including statutory authority, regulatory rules, examiner guidance, and practice notes. It is provided as guidance, with links to the ground truth sources. This is information only, it is not legal advice.

Notification of a Failure to Comply with Sequence Listing Requirements and Amendments Relating to “Sequence Listing XML” Files Under 37 CFR 1.835

This section addresses Notification of a Failure to Comply with Sequence Listing Requirements and Amendments Relating to “Sequence Listing XML” Files Under 37 CFR 1.835. Primary authority: 35 U.S.C. 111(a), 37 CFR 1.831, and 37 CFR 1.835(a)). Contains: 2 requirements, 1 permission, and 1 other statement.

Key Rules

Topic

Sequence Listing Content

3 rules
StatutoryInformativeAlways
[mpep-2414-0108c13bdbef79e3c26d102e]
Nucleotide and Amino Acid Sequence Disclosure Requirement
Note:
All applications filed on or after July 1, 2022, must disclose one or more nucleotide and/or amino acid sequences as defined in 37 CFR 1.831(b).

[Editor Note: This section is applicable to all applications with a filing date, or, for national phase applications, an international filing date, on or after July 1, 2022, having disclosure of one or more nucleotide and/or amino acid sequences as defined in 37 CFR 1.831(b).]

37 CFR 1.77 · 37 CFR 1.831(b)Sequence Listing ContentSequence Listing RequirementsSequence Listing Format
StatutoryRequiredAlways
[mpep-2414-2f1767a4232ada253c15e9e9]
Sequence Listing XML Required for Nucleotide and Amino Acid Sequences
Note:
For applications filed on or after July 1, 2022, containing nucleotide and/or amino acid sequences, a compliant 'Sequence Listing XML' is mandatory.

When an application filed under 35 U.S.C. 111(a) having a filing date on or after July 1, 2022, or an application which entered the national stage, having an international filing date on or after July 1, 2022, contains disclosure of nucleotide and/or amino acid sequences, a “Sequence Listing XML” is required. When no “Sequence Listing XML” or a defective “Sequence Listing XML” is submitted in an application where a compliant “Sequence Listing XML” is required, the pre-examination staff will issue a notification that compliance with 37 CFR 1.831 – 1.835 is required and an added initial submission of a “Sequence Listing XML” (37 CFR 1.835(a)) or replacement “Sequence Listing XML” (37 CFR 1.835(b)) will be required. Additionally, the examiner can require the filing of a “Sequence Listing XML” if an application fails to comply with 37 CFR 1.831 – 1.834. For example, if there are sequences in the disclosure which are not part of the “Sequence Listing XML” of record, then the examiner can require a replacement “Sequence Listing XML” which includes the omitted sequences. See form paragraphs 24.18.26 – 24.20.26, 24.23.26, and 24.27.26-24.28.26.

Jump to MPEP Source · 37 CFR 1.831Sequence Listing ContentSequence Listing FormatSequence Listing Requirements
StatutoryInformativeAlways
[mpep-2414-bd4efbb5b0bbe66c386e105c]
Sequence Listing XML Required for Nucleotide and Amino Acid Sequences
Note:
When an application contains nucleotide or amino acid sequences, a compliant Sequence Listing XML is required. Failure to submit one will result in notification of compliance requirements.

When an application filed under 35 U.S.C. 111(a) having a filing date on or after July 1, 2022, or an application which entered the national stage, having an international filing date on or after July 1, 2022, contains disclosure of nucleotide and/or amino acid sequences, a “Sequence Listing XML” is required. When no “Sequence Listing XML” or a defective “Sequence Listing XML” is submitted in an application where a compliant “Sequence Listing XML” is required, the pre-examination staff will issue a notification that compliance with 37 CFR 1.831 – 1.835 is required and an added initial submission of a “Sequence Listing XML” (37 CFR 1.835(a)) or replacement “Sequence Listing XML” (37 CFR 1.835(b)) will be required. Additionally, the examiner can require the filing of a “Sequence Listing XML” if an application fails to comply with 37 CFR 1.831 – 1.834. For example, if there are sequences in the disclosure which are not part of the “Sequence Listing XML” of record, then the examiner can require a replacement “Sequence Listing XML” which includes the omitted sequences. See form paragraphs 24.18.26 – 24.20.26, 24.23.26, and 24.27.26-24.28.26.

Jump to MPEP Source · 37 CFR 1.831Sequence Listing ContentSequence Listing FormatSequence Listing Requirements
Topic

Sequence Listing Format

2 rules
StatutoryRequiredAlways
[mpep-2414-65a7952322668e8d884eec3b]
Sequence Listing XML Required for Nucleotide and Amino Acid Sequences
Note:
When an application contains nucleotide or amino acid sequences, a compliant Sequence Listing XML must be submitted. If not provided or defective, the examiner will require its submission.

When an application filed under 35 U.S.C. 111(a) having a filing date on or after July 1, 2022, or an application which entered the national stage, having an international filing date on or after July 1, 2022, contains disclosure of nucleotide and/or amino acid sequences, a “Sequence Listing XML” is required. When no “Sequence Listing XML” or a defective “Sequence Listing XML” is submitted in an application where a compliant “Sequence Listing XML” is required, the pre-examination staff will issue a notification that compliance with 37 CFR 1.831 – 1.835 is required and an added initial submission of a “Sequence Listing XML” (37 CFR 1.835(a)) or replacement “Sequence Listing XML” (37 CFR 1.835(b)) will be required. Additionally, the examiner can require the filing of a “Sequence Listing XML” if an application fails to comply with 37 CFR 1.831 – 1.834. For example, if there are sequences in the disclosure which are not part of the “Sequence Listing XML” of record, then the examiner can require a replacement “Sequence Listing XML” which includes the omitted sequences. See form paragraphs 24.18.26 – 24.20.26, 24.23.26, and 24.27.26-24.28.26.

Jump to MPEP Source · 37 CFR 1.831Sequence Listing FormatSequence Listing RequirementsSequence Listing Content
StatutoryPermittedAlways
[mpep-2414-9aa157d786ea48b7e8ccb1ef]
Examiner Can Require Updated Sequence Listing XML
Note:
If sequences in the disclosure are not included in the current ‘Sequence Listing XML’, the examiner can require a replacement ‘Sequence Listing XML’ that includes all omitted sequences.

When an application filed under 35 U.S.C. 111(a) having a filing date on or after July 1, 2022, or an application which entered the national stage, having an international filing date on or after July 1, 2022, contains disclosure of nucleotide and/or amino acid sequences, a “Sequence Listing XML” is required. When no “Sequence Listing XML” or a defective “Sequence Listing XML” is submitted in an application where a compliant “Sequence Listing XML” is required, the pre-examination staff will issue a notification that compliance with 37 CFR 1.831 – 1.835 is required and an added initial submission of a “Sequence Listing XML” (37 CFR 1.835(a)) or replacement “Sequence Listing XML” (37 CFR 1.835(b)) will be required. Additionally, the examiner can require the filing of a “Sequence Listing XML” if an application fails to comply with 37 CFR 1.831 – 1.834. For example, if there are sequences in the disclosure which are not part of the “Sequence Listing XML” of record, then the examiner can require a replacement “Sequence Listing XML” which includes the omitted sequences. See form paragraphs 24.18.26 – 24.20.26, 24.23.26, and 24.27.26-24.28.26.

Jump to MPEP Source · 37 CFR 1.831Sequence Listing FormatSequence Listing RequirementsSequence Listing Content

Citations

Primary topicCitation
Sequence Listing Content
Sequence Listing Format
35 U.S.C. § 111(a)
Sequence Listing Content
Sequence Listing Format
37 CFR § 1.831
Sequence Listing Content37 CFR § 1.831(b)
Sequence Listing Content
Sequence Listing Format
37 CFR § 1.835(a)
Sequence Listing Content
Sequence Listing Format
37 CFR § 1.835(b)

Source Text from USPTO’s MPEP

This is an exact copy of the MPEP from the USPTO. It is here for your reference to see the section in context.

BlueIron Last Updated: 2025-12-31