[Editor Note: This section is applicable to all applications with a filing date, or, for national phase applications, an international filing date, on or after July 1, 2022, having disclosure of one or more nucleotide and/or amino acid sequences as defined in 37 CFR 1.831(b).]

For all applications that disclose a nucleotide sequence and/or amino acid sequence(s) by enumeration of its residues, as defined in 37 CFR 1.831(b), 37 CFR 1.831(a) requires conformance to the requirements of 37 CFR 1.832 through 37 CFR 1.834 with regard to the manner in which the disclosed nucleotide and/or amino acid sequences are presented and described in the “Sequence Listing XML.” This requirement is necessary to minimize any confusion that could result if more than one format for representing sequence data was employed in a given application.

Pursuant to 37 CFR 1.83(a), sequences that are included in the “Sequence Listing XML” should not be duplicated in the drawings. With the use of feature keys and qualifiers in a “Sequence Listing XML” to represent and describe features of a nucleotide or amino acid sequence, the need to re-present a sequence in a drawing is less critical. However, in certain instances, a significant sequence characteristic may not be readily conveyed by the sequence-associated data of the “Sequence Listing XML” and may need to be depicted in a figure. For example, in view of the fact that the representation of double stranded nucleic acids is not permitted in the “Sequence Listing XML,” many significant nucleic acid features, such as “sticky ends” and the like, may only be shown effectively by reference to a drawing figure. Further, the similarity or homology between/among sequences may only be depicted in an effective manner in a drawing figure. Similarly, drawing figures are recommended for use with amino acid sequences to depict structural features of the corresponding protein, such as epitopes and interaction domains. The situations discussed herein are given by way of example only and there may be many other reasons for including a sequence in a drawing. However, when an enumerated sequence is presented in a drawing, the sequence must still be included in the “Sequence Listing XML” if the sequence falls within the definition set forth in 37 CFR 1.831(b), and a sequence identifier (preceded by “SEQ ID NO:X” or the like) must be used, either in the drawing itself or in the Brief Description of the Drawings.

Pursuant to 37 CFR 1.83(a), sequences that are included in the “Sequence Listing XML” should not be duplicated in the drawings. With the use of feature keys and qualifiers in a “Sequence Listing XML” to represent and describe features of a nucleotide or amino acid sequence, the need to re-present a sequence in a drawing is less critical. However, in certain instances, a significant sequence characteristic may not be readily conveyed by the sequence-associated data of the “Sequence Listing XML” and may need to be depicted in a figure. For example, in view of the fact that the representation of double stranded nucleic acids is not permitted in the “Sequence Listing XML,” many significant nucleic acid features, such as “sticky ends” and the like, may only be shown effectively by reference to a drawing figure. Further, the similarity or homology between/among sequences may only be depicted in an effective manner in a drawing figure. Similarly, drawing figures are recommended for use with amino acid sequences to depict structural features of the corresponding protein, such as epitopes and interaction domains. The situations discussed herein are given by way of example only and there may be many other reasons for including a sequence in a drawing. However, when an enumerated sequence is presented in a drawing, the sequence must still be included in the “Sequence Listing XML” if the sequence falls within the definition set forth in 37 CFR 1.831(b), and a sequence identifier (preceded by “SEQ ID NO:X” or the like) must be used, either in the drawing itself or in the Brief Description of the Drawings.

Pursuant to 37 CFR 1.83(a), sequences that are included in the “Sequence Listing XML” should not be duplicated in the drawings. With the use of feature keys and qualifiers in a “Sequence Listing XML” to represent and describe features of a nucleotide or amino acid sequence, the need to re-present a sequence in a drawing is less critical. However, in certain instances, a significant sequence characteristic may not be readily conveyed by the sequence-associated data of the “Sequence Listing XML” and may need to be depicted in a figure. For example, in view of the fact that the representation of double stranded nucleic acids is not permitted in the “Sequence Listing XML,” many significant nucleic acid features, such as “sticky ends” and the like, may only be shown effectively by reference to a drawing figure. Further, the similarity or homology between/among sequences may only be depicted in an effective manner in a drawing figure. Similarly, drawing figures are recommended for use with amino acid sequences to depict structural features of the corresponding protein, such as epitopes and interaction domains. The situations discussed herein are given by way of example only and there may be many other reasons for including a sequence in a drawing. However, when an enumerated sequence is presented in a drawing, the sequence must still be included in the “Sequence Listing XML” if the sequence falls within the definition set forth in 37 CFR 1.831(b), and a sequence identifier (preceded by “SEQ ID NO:X” or the like) must be used, either in the drawing itself or in the Brief Description of the Drawings.

Pursuant to 37 CFR 1.83(a), sequences that are included in the “Sequence Listing XML” should not be duplicated in the drawings. With the use of feature keys and qualifiers in a “Sequence Listing XML” to represent and describe features of a nucleotide or amino acid sequence, the need to re-present a sequence in a drawing is less critical. However, in certain instances, a significant sequence characteristic may not be readily conveyed by the sequence-associated data of the “Sequence Listing XML” and may need to be depicted in a figure. For example, in view of the fact that the representation of double stranded nucleic acids is not permitted in the “Sequence Listing XML,” many significant nucleic acid features, such as “sticky ends” and the like, may only be shown effectively by reference to a drawing figure. Further, the similarity or homology between/among sequences may only be depicted in an effective manner in a drawing figure. Similarly, drawing figures are recommended for use with amino acid sequences to depict structural features of the corresponding protein, such as epitopes and interaction domains. The situations discussed herein are given by way of example only and there may be many other reasons for including a sequence in a drawing. However, when an enumerated sequence is presented in a drawing, the sequence must still be included in the “Sequence Listing XML” if the sequence falls within the definition set forth in 37 CFR 1.831(b), and a sequence identifier (preceded by “SEQ ID NO:X” or the like) must be used, either in the drawing itself or in the Brief Description of the Drawings.

For all applications that disclose a nucleotide sequence and/or amino acid sequence(s) by enumeration of its residues, as defined in 37 CFR 1.831(b), 37 CFR 1.831(a) requires conformance to the requirements of 37 CFR 1.832 through 37 CFR 1.834 with regard to the manner in which the disclosed nucleotide and/or amino acid sequences are presented and described in the “Sequence Listing XML.” This requirement is necessary to minimize any confusion that could result if more than one format for representing sequence data was employed in a given application.

Pursuant to 37 CFR 1.83(a), sequences that are included in the “Sequence Listing XML” should not be duplicated in the drawings. With the use of feature keys and qualifiers in a “Sequence Listing XML” to represent and describe features of a nucleotide or amino acid sequence, the need to re-present a sequence in a drawing is less critical. However, in certain instances, a significant sequence characteristic may not be readily conveyed by the sequence-associated data of the “Sequence Listing XML” and may need to be depicted in a figure. For example, in view of the fact that the representation of double stranded nucleic acids is not permitted in the “Sequence Listing XML,” many significant nucleic acid features, such as “sticky ends” and the like, may only be shown effectively by reference to a drawing figure. Further, the similarity or homology between/among sequences may only be depicted in an effective manner in a drawing figure. Similarly, drawing figures are recommended for use with amino acid sequences to depict structural features of the corresponding protein, such as epitopes and interaction domains. The situations discussed herein are given by way of example only and there may be many other reasons for including a sequence in a drawing. However, when an enumerated sequence is presented in a drawing, the sequence must still be included in the “Sequence Listing XML” if the sequence falls within the definition set forth in 37 CFR 1.831(b), and a sequence identifier (preceded by “SEQ ID NO:X” or the like) must be used, either in the drawing itself or in the Brief Description of the Drawings.