MPEP § 716.02(c) — Weighing Evidence of Expected and Unexpected Results (Annotated Rules)

§716.02(c) Weighing Evidence of Expected and Unexpected Results

USPTO MPEP version: BlueIron's Update: 2025-12-31

This page consolidates and annotates all enforceable requirements under MPEP § 716.02(c), including statutory authority, regulatory rules, examiner guidance, and practice notes. It is provided as guidance, with links to the ground truth sources. This is information only, it is not legal advice.

Weighing Evidence of Expected and Unexpected Results

This section addresses Weighing Evidence of Expected and Unexpected Results. Contains: 1 requirement, 1 prohibition, and 6 other statements.

Key Rules

Topic

Rebutting Prima Facie Case

4 rules
MPEP GuidanceInformativeAlways
[mpep-716-02-c-74d8225023b19c92eb0362ba]
Unexpected Results Weigh Against Obviousness
Note:
Evidence showing an unexpected result, such as a compound being nonaddictive, can outweigh evidence supporting a prima facie case of obviousness.

Evidence of unexpected results must be weighed against evidence supporting prima facie obviousness in making a final determination of the obviousness of the claimed invention. In re May, 574 F.2d 1082, 197 USPQ 601 (CCPA 1978) (Claims directed to a method of effecting analgesia without producing physical dependence by administering the levo isomer of a compound having a certain chemical structure were rejected as obvious over the prior art. Evidence that the compound was unexpectedly nonaddictive was sufficient to overcome the obviousness rejection. Although the compound also had the expected result of potent analgesia, there was evidence of record showing that the goal of research in this area was to produce an analgesic compound which was nonaddictive, enhancing the evidentiary value of the showing of nonaddictiveness as an indicium of nonobviousness.). See MPEP § 716.01(d) for guidance on weighing evidence submitted to traverse a rejection.

Jump to MPEP SourceRebutting Prima Facie CaseObviousness
MPEP GuidanceInformativeAlways
[mpep-716-02-c-c9b60167b459038e008828bb]
Showing Nonaddictiveness as Evidence of Nonobviousness
Note:
The rule requires showing nonaddictiveness to be considered evidence of nonobviousness when the goal was to produce a nonaddictive analgesic compound.

Evidence of unexpected results must be weighed against evidence supporting prima facie obviousness in making a final determination of the obviousness of the claimed invention. In re May, 574 F.2d 1082, 197 USPQ 601 (CCPA 1978) (Claims directed to a method of effecting analgesia without producing physical dependence by administering the levo isomer of a compound having a certain chemical structure were rejected as obvious over the prior art. Evidence that the compound was unexpectedly nonaddictive was sufficient to overcome the obviousness rejection. Although the compound also had the expected result of potent analgesia, there was evidence of record showing that the goal of research in this area was to produce an analgesic compound which was nonaddictive, enhancing the evidentiary value of the showing of nonaddictiveness as an indicium of nonobviousness.). See MPEP § 716.01(d) for guidance on weighing evidence submitted to traverse a rejection.

Jump to MPEP SourceRebutting Prima Facie CaseObviousnessPrima Facie Case of Obviousness
MPEP GuidanceProhibitedAlways
[mpep-716-02-c-07b18b169fa17337f31b4883]
Unexpected Properties Must Equal Expected to Rebut Obviousness
Note:
The evidence of unexpected properties must be as significant as expected properties to rebut a prima facie case of obviousness.

Where the unexpected properties of a claimed invention are not shown to have a significance equal to or greater than the expected properties, the evidence of unexpected properties may not be sufficient to rebut the evidence of obviousness. In re Nolan, 553 F.2d 1261, 1267, 193 USPQ 641, 645 (CCPA 1977) (Claims were directed to a display/memory device which was prima facie obvious over the prior art. The court found that a higher memory margin and lower operating voltage would have been expected properties of the claimed device, and that a higher memory margin appears to be the most significant improvement for a memory device. Although applicant presented evidence of unexpected properties with regard to lower peak discharge current and higher luminous efficiency, these properties were not shown to have a significance equal to or greater than that of the expected higher memory margin and lower operating voltage. The court held the evidence of nonobviousness was not sufficient to rebut the evidence of obviousness.); In re Eli Lilly, 902 F.2d 943, 14 USPQ2d 1741 (Fed. Cir. 1990) (Evidence of improved feed efficiency in steers was not sufficient to rebut prima facie case of obviousness based on prior art which specifically taught the use of compound X537A to enhance weight gain in animals because the evidence did not show that a significant aspect of the claimed invention would have been unexpected.).

Jump to MPEP SourceRebutting Prima Facie CasePrima Facie Case of ObviousnessObviousness
MPEP GuidanceInformativeAlways
[mpep-716-02-c-edfa110838b22ea574b5f47f]
Unexpected Properties Must Equal Expected Improvements to Rebut Obviousness
Note:
The evidence of unexpected properties must be as significant as the expected improvements to rebut a prima facie case of obviousness.

Where the unexpected properties of a claimed invention are not shown to have a significance equal to or greater than the expected properties, the evidence of unexpected properties may not be sufficient to rebut the evidence of obviousness. In re Nolan, 553 F.2d 1261, 1267, 193 USPQ 641, 645 (CCPA 1977) (Claims were directed to a display/memory device which was prima facie obvious over the prior art. The court found that a higher memory margin and lower operating voltage would have been expected properties of the claimed device, and that a higher memory margin appears to be the most significant improvement for a memory device. Although applicant presented evidence of unexpected properties with regard to lower peak discharge current and higher luminous efficiency, these properties were not shown to have a significance equal to or greater than that of the expected higher memory margin and lower operating voltage. The court held the evidence of nonobviousness was not sufficient to rebut the evidence of obviousness.); In re Eli Lilly, 902 F.2d 943, 14 USPQ2d 1741 (Fed. Cir. 1990) (Evidence of improved feed efficiency in steers was not sufficient to rebut prima facie case of obviousness based on prior art which specifically taught the use of compound X537A to enhance weight gain in animals because the evidence did not show that a significant aspect of the claimed invention would have been unexpected.).

Jump to MPEP SourceRebutting Prima Facie CaseObviousness
Topic

Establishing Prima Facie Case

3 rules
MPEP GuidanceInformativeAlways
[mpep-716-02-c-d40193970b4d1347b2c6bf7f]
Significance of Unexpected Properties Not Exceeding Expected
Note:
If unexpected properties are not as significant as expected properties, evidence of non-obviousness is insufficient to rebut a prima facie case of obviousness.

Where the unexpected properties of a claimed invention are not shown to have a significance equal to or greater than the expected properties, the evidence of unexpected properties may not be sufficient to rebut the evidence of obviousness. In re Nolan, 553 F.2d 1261, 1267, 193 USPQ 641, 645 (CCPA 1977) (Claims were directed to a display/memory device which was prima facie obvious over the prior art. The court found that a higher memory margin and lower operating voltage would have been expected properties of the claimed device, and that a higher memory margin appears to be the most significant improvement for a memory device. Although applicant presented evidence of unexpected properties with regard to lower peak discharge current and higher luminous efficiency, these properties were not shown to have a significance equal to or greater than that of the expected higher memory margin and lower operating voltage. The court held the evidence of nonobviousness was not sufficient to rebut the evidence of obviousness.); In re Eli Lilly, 902 F.2d 943, 14 USPQ2d 1741 (Fed. Cir. 1990) (Evidence of improved feed efficiency in steers was not sufficient to rebut prima facie case of obviousness based on prior art which specifically taught the use of compound X537A to enhance weight gain in animals because the evidence did not show that a significant aspect of the claimed invention would have been unexpected.).

Jump to MPEP SourceEstablishing Prima Facie CaseRebutting Prima Facie CasePrima Facie Case of Obviousness
MPEP GuidanceInformativeAlways
[mpep-716-02-c-798f6d061820f88ddd5ce15a]
Significance of Unexpected Properties Must Equal Expected Improvements
Note:
The evidence of unexpected properties must be as significant as the expected improvements to rebut a prima facie case of obviousness.

Where the unexpected properties of a claimed invention are not shown to have a significance equal to or greater than the expected properties, the evidence of unexpected properties may not be sufficient to rebut the evidence of obviousness. In re Nolan, 553 F.2d 1261, 1267, 193 USPQ 641, 645 (CCPA 1977) (Claims were directed to a display/memory device which was prima facie obvious over the prior art. The court found that a higher memory margin and lower operating voltage would have been expected properties of the claimed device, and that a higher memory margin appears to be the most significant improvement for a memory device. Although applicant presented evidence of unexpected properties with regard to lower peak discharge current and higher luminous efficiency, these properties were not shown to have a significance equal to or greater than that of the expected higher memory margin and lower operating voltage. The court held the evidence of nonobviousness was not sufficient to rebut the evidence of obviousness.); In re Eli Lilly, 902 F.2d 943, 14 USPQ2d 1741 (Fed. Cir. 1990) (Evidence of improved feed efficiency in steers was not sufficient to rebut prima facie case of obviousness based on prior art which specifically taught the use of compound X537A to enhance weight gain in animals because the evidence did not show that a significant aspect of the claimed invention would have been unexpected.).

Jump to MPEP SourceEstablishing Prima Facie CaseRebutting Prima Facie CasePrima Facie Case of Obviousness
MPEP GuidanceInformativeAlways
[mpep-716-02-c-88ac991852acdc51cd051c11]
Unexpected Results Must Significantly Exceed Expected
Note:
The evidence of unexpected results must significantly exceed the expected results to rebut a prima facie case of obviousness.

Where the unexpected properties of a claimed invention are not shown to have a significance equal to or greater than the expected properties, the evidence of unexpected properties may not be sufficient to rebut the evidence of obviousness. In re Nolan, 553 F.2d 1261, 1267, 193 USPQ 641, 645 (CCPA 1977) (Claims were directed to a display/memory device which was prima facie obvious over the prior art. The court found that a higher memory margin and lower operating voltage would have been expected properties of the claimed device, and that a higher memory margin appears to be the most significant improvement for a memory device. Although applicant presented evidence of unexpected properties with regard to lower peak discharge current and higher luminous efficiency, these properties were not shown to have a significance equal to or greater than that of the expected higher memory margin and lower operating voltage. The court held the evidence of nonobviousness was not sufficient to rebut the evidence of obviousness.); In re Eli Lilly, 902 F.2d 943, 14 USPQ2d 1741 (Fed. Cir. 1990) (Evidence of improved feed efficiency in steers was not sufficient to rebut prima facie case of obviousness based on prior art which specifically taught the use of compound X537A to enhance weight gain in animals because the evidence did not show that a significant aspect of the claimed invention would have been unexpected.).

Jump to MPEP SourceEstablishing Prima Facie CaseRebutting Prima Facie CasePrima Facie Case of Obviousness
Topic

Prima Facie Case of Obviousness

1 rules
MPEP GuidanceRequiredAlways
[mpep-716-02-c-c7c551ea4fb67d78862f2475]
Unexpected Results vs. Prima Facie Obviousness
Note:
Weigh evidence of unexpected results against prima facie obviousness to determine the obviousness of an invention.

Evidence of unexpected results must be weighed against evidence supporting prima facie obviousness in making a final determination of the obviousness of the claimed invention. In re May, 574 F.2d 1082, 197 USPQ 601 (CCPA 1978) (Claims directed to a method of effecting analgesia without producing physical dependence by administering the levo isomer of a compound having a certain chemical structure were rejected as obvious over the prior art. Evidence that the compound was unexpectedly nonaddictive was sufficient to overcome the obviousness rejection. Although the compound also had the expected result of potent analgesia, there was evidence of record showing that the goal of research in this area was to produce an analgesic compound which was nonaddictive, enhancing the evidentiary value of the showing of nonaddictiveness as an indicium of nonobviousness.). See MPEP § 716.01(d) for guidance on weighing evidence submitted to traverse a rejection.

Jump to MPEP SourcePrima Facie Case of ObviousnessObviousness
Topic

Claims Directed To

1 rules
MPEP GuidanceInformativeAlways
[mpep-716-02-c-a148cd2cc893cc31729e7b46]
Evidence of Expected vs Unexpected Results for Obviousness
Note:
The rule states that expected results from prior art can prove a claimed invention is obvious, while unexpected results show it is not.

“Expected beneficial results are evidence of obviousness of a claimed invention, just as unexpected results are evidence of unobviousness thereof.” In re Gershon, 372 F.2d 535, 538, 152 USPQ 602, 604 (CCPA 1967) (resultant decrease of dental enamel solubility accomplished by adding an acidic buffering agent to a fluoride containing dentifrice was expected based on the teaching of the prior art); Ex parte Blanc, 13 USPQ2d 1383 (Bd. Pat. App. & Inter. 1989) (Claims at issue were directed to a process of sterilizing a polyolefinic composition which contains an antioxidant with high-energy radiation. Although evidence was presented in appellant’s specification showing that particular antioxidants are effective, the Board concluded that these beneficial results would have been expected because one of the references taught a claimed antioxidant is very efficient and provides better results compared with other prior art antioxidants.).

Jump to MPEP SourceClaims Directed ToClaim Subject Matter
Topic

Claims

1 rules
MPEP GuidanceInformativeAlways
[mpep-716-02-c-b3f6c05597d2d86088af588d]
Expected Results from Antioxidants
Note:
The rule states that evidence showing particular antioxidants are effective is not sufficient to prove the claimed invention's non-obviousness if a reference teaches an efficient antioxidant providing better results than other prior art.

“Expected beneficial results are evidence of obviousness of a claimed invention, just as unexpected results are evidence of unobviousness thereof.” In re Gershon, 372 F.2d 535, 538, 152 USPQ 602, 604 (CCPA 1967) (resultant decrease of dental enamel solubility accomplished by adding an acidic buffering agent to a fluoride containing dentifrice was expected based on the teaching of the prior art); Ex parte Blanc, 13 USPQ2d 1383 (Bd. Pat. App. & Inter. 1989) (Claims at issue were directed to a process of sterilizing a polyolefinic composition which contains an antioxidant with high-energy radiation. Although evidence was presented in appellant’s specification showing that particular antioxidants are effective, the Board concluded that these beneficial results would have been expected because one of the references taught a claimed antioxidant is very efficient and provides better results compared with other prior art antioxidants.).

Jump to MPEP SourcePTAB JurisdictionPatent Application Content

Citations

Primary topicCitation
Prima Facie Case of Obviousness
Rebutting Prima Facie Case
MPEP § 716.01(d)
Establishing Prima Facie Case
Rebutting Prima Facie Case
In re Eli Lilly, 902 F.2d 943, 14 USPQ2d 1741 (Fed. Cir. 1990)
Claims
Claims Directed To
In re Gershon, 372 F.2d 535, 538, 152 USPQ 602, 604 (CCPA 1967)
Prima Facie Case of Obviousness
Rebutting Prima Facie Case
In re May, 574 F.2d 1082, 197 USPQ 601 (CCPA 1978)
Establishing Prima Facie Case
Rebutting Prima Facie Case
In re Nolan, 553 F.2d 1261, 1267, 193 USPQ 641, 645 (CCPA 1977)

Source Text from USPTO’s MPEP

This is an exact copy of the MPEP from the USPTO. It is here for your reference to see the section in context.

BlueIron Last Updated: 2025-12-31