MPEP § 2424.02 — “Sequence Listing” Numeric Identifiers (Annotated Rules)

§2424.02 “Sequence Listing” Numeric Identifiers

USPTO MPEP version: BlueIron's Update: 2025-12-31

This page consolidates and annotates all enforceable requirements under MPEP § 2424.02, including statutory authority, regulatory rules, examiner guidance, and practice notes. It is provided as guidance, with links to the ground truth sources. This is information only, it is not legal advice.

“Sequence Listing” Numeric Identifiers

This section addresses “Sequence Listing” Numeric Identifiers. Primary authority: 37 CFR 1.823(a). Contains: 3 requirements and 3 other statements.

Key Rules

Topic

Sequence Listing Format

3 rules
StatutoryInformativeAlways
[mpep-2424-02-5bd0544fd81febc899cb8c6a]
Order and Presentation of Sequence Listing Items Required
Note:
Each item in the sequence listing must begin on a new line with an appropriate numeric identifier enclosed in angle brackets, and mandatory items designated with 'M' must be submitted.

37 CFR 1.823(a) sets forth the order and presentation of the items of information in the “Sequence Listing”. Each item of information in the “Sequence Listing” must include the appropriate numeric identifier and its accompanying information as in Appendix G to Subpart G of Part 1. Each item of information must begin on a new line with the numeric identifier enclosed in angle brackets. The submission of those items of information designated with an “M” is mandatory. The submission of those items of information designated with an “O” is optional. Numeric identifiers <110> through <170> must be set forth at the beginning of the “Sequence Listing”.

Jump to MPEP Source · 37 CFR 1.823(a)Sequence Listing FormatSupplemental Examination RequestSequence Listing Requirements
StatutoryRequiredAlways
[mpep-2424-02-2fee753b080d0d3957573888]
Numeric Identifiers for Sequence Listing Required
Note:
Numeric identifiers from <110> to <170> must be included at the beginning of the 'Sequence Listing'.

37 CFR 1.823(a) sets forth the order and presentation of the items of information in the “Sequence Listing”. Each item of information in the “Sequence Listing” must include the appropriate numeric identifier and its accompanying information as in Appendix G to Subpart G of Part 1. Each item of information must begin on a new line with the numeric identifier enclosed in angle brackets. The submission of those items of information designated with an “M” is mandatory. The submission of those items of information designated with an “O” is optional. Numeric identifiers <110> through <170> must be set forth at the beginning of the “Sequence Listing”.

Jump to MPEP Source · 37 CFR 1.823(a)Sequence Listing FormatSequence Listing RequirementsRequest Content Requirements
StatutoryInformativeAlways
[mpep-2424-02-e9362bad4997f473768f8d48]
Sample Sequence Listing Required
Note:
A sample sequence listing must be provided as per MPEP § 2431.

See MPEP § 2431 for a sample “Sequence Listing”.

Jump to MPEP SourceSequence Listing FormatSequence Listing Requirements
Topic

Request Content Requirements

2 rules
StatutoryRequiredAlways
[mpep-2424-02-a232ffba5c742e61db5cedb0]
Sequence Listing Numeric Identifiers Required
Note:
Each item in the Sequence Listing must include a numeric identifier and its information as specified in Appendix G to Subpart G of Part 1.

37 CFR 1.823(a) sets forth the order and presentation of the items of information in the “Sequence Listing”. Each item of information in the “Sequence Listing” must include the appropriate numeric identifier and its accompanying information as in Appendix G to Subpart G of Part 1. Each item of information must begin on a new line with the numeric identifier enclosed in angle brackets. The submission of those items of information designated with an “M” is mandatory. The submission of those items of information designated with an “O” is optional. Numeric identifiers <110> through <170> must be set forth at the beginning of the “Sequence Listing”.

Jump to MPEP Source · 37 CFR 1.823(a)Request Content RequirementsSequence Listing ContentSequence Listing Format
StatutoryRequiredAlways
[mpep-2424-02-194aba1c2e195fa9463a79de]
Numeric Identifiers Must Begin New Line in Sequence Listing
Note:
Each item of information in the Sequence Listing must start on a new line with numeric identifiers enclosed in angle brackets.

37 CFR 1.823(a) sets forth the order and presentation of the items of information in the “Sequence Listing”. Each item of information in the “Sequence Listing” must include the appropriate numeric identifier and its accompanying information as in Appendix G to Subpart G of Part 1. Each item of information must begin on a new line with the numeric identifier enclosed in angle brackets. The submission of those items of information designated with an “M” is mandatory. The submission of those items of information designated with an “O” is optional. Numeric identifiers <110> through <170> must be set forth at the beginning of the “Sequence Listing”.

Jump to MPEP Source · 37 CFR 1.823(a)Request Content RequirementsSequence Listing ContentSequence Listing Format
Topic

Supplemental Examination Request

2 rules
StatutoryInformativeAlways
[mpep-2424-02-3472c03424f47a8f93c3ac4d]
Mandatory Submission of Designated Information
Note:
Items designated with an 'M' must be submitted in the Sequence Listing as per 37 CFR 1.823(a).

37 CFR 1.823(a) sets forth the order and presentation of the items of information in the “Sequence Listing”. Each item of information in the “Sequence Listing” must include the appropriate numeric identifier and its accompanying information as in Appendix G to Subpart G of Part 1. Each item of information must begin on a new line with the numeric identifier enclosed in angle brackets. The submission of those items of information designated with an “M” is mandatory. The submission of those items of information designated with an “O” is optional. Numeric identifiers <110> through <170> must be set forth at the beginning of the “Sequence Listing”.

Jump to MPEP Source · 37 CFR 1.823(a)Supplemental Examination RequestSupplemental ExaminationRequest Content Requirements
StatutoryInformativeAlways
[mpep-2424-02-692570fd5eead3c7ca938e40]
Optional Submission of Designated Information
Note:
Items designated with an 'O' in the Sequence Listing are not mandatory to submit.

37 CFR 1.823(a) sets forth the order and presentation of the items of information in the “Sequence Listing”. Each item of information in the “Sequence Listing” must include the appropriate numeric identifier and its accompanying information as in Appendix G to Subpart G of Part 1. Each item of information must begin on a new line with the numeric identifier enclosed in angle brackets. The submission of those items of information designated with an “M” is mandatory. The submission of those items of information designated with an “O” is optional. Numeric identifiers <110> through <170> must be set forth at the beginning of the “Sequence Listing”.

Jump to MPEP Source · 37 CFR 1.823(a)Supplemental Examination RequestSupplemental ExaminationRequest Content Requirements
Topic

Sequence Listing Content

1 rules
StatutoryInformativeAlways
[mpep-2424-02-f0efb69e837416d93b836b59]
Requirement for Sequence Listings
Note:
This rule requires that applications disclose nucleotide and/or amino acid sequences in a specified format, unless filed after July 1, 2022.

[Editor Note: This section is not applicable to applications filed on or after July 1, 2022, having disclosures of nucleotide and/or amino acid sequences as defined in 37 CFR 1.831(b). See MPEP §§ 2412 – 2419 for guidance on WIPO ST.26 requirements for applications filed on or after July 1, 2022.]

37 CFR 1.77 · 37 CFR 1.831(b)Sequence Listing ContentSequence Listing RequirementsSequence Listing Format

Citations

Primary topicCitation
Request Content Requirements
Sequence Listing Format
Supplemental Examination Request
37 CFR § 1.823(a)
Sequence Listing Content37 CFR § 1.831(b)
Sequence Listing ContentMPEP § 2412
Sequence Listing FormatMPEP § 2431

Source Text from USPTO’s MPEP

This is an exact copy of the MPEP from the USPTO. It is here for your reference to see the section in context.

BlueIron Last Updated: 2025-12-31