What is considered a “nucleotide” in a Sequence Listing XML?

According to MPEP 2412.03(d), a “nucleotide” in a Sequence Listing XML includes:

  • Any nucleotide
  • Nucleotide analogs
  • Modified nucleotides

The MPEP, citing WIPO Standard ST.26, specifies that a nucleotide must contain:

  1. A backbone moiety (e.g., 2′ deoxyribose 5′ monophosphate or an analogue)
  2. Either a nucleobase (including modified or synthetic purines or pyrimidines) or an “AP site” (abasic site)

Nucleotide analogs that mimic the arrangement of nucleobases in natural nucleic acids and can base pair with complementary nucleic acids are also included in this definition.

To learn more:

Topics: MPEP 2400 - Biotechnology, MPEP 2412.03 - Nucleotides And Amino Acids Included And Excluded From A "Sequence Listing Xml", Patent Law, Patent Procedure
Tags: Modified Nucleotides, Nucleotide Analogs, Nucleotides, sequence listing xml, wipo standard st.26