What is a “Sequence Listing XML” and why must it be valid according to the DTD?

This page is an FAQ based on guidance from the Manual of Patent Examining Procedure. It is provided as guidance, with links to the ground truth sources. This is information only: it is not legal advice.

A “Sequence Listing XML” is a standardized format for presenting nucleotide and/or amino acid sequences in patent applications. It must be valid according to the Document Type Definition (DTD) as specified in MPEP § 2413.01(b) and 37 CFR 1.833(b)(1).

The MPEP states: “The ‘Sequence Listing XML’ presented in accordance with paragraph (a) of this section must further: (1) Be valid according to the Document Type Definition (DTD) as presented in WIPO Standard ST.26, Annex II.”

This requirement ensures that the sequence listing conforms to a standardized structure, facilitating automated processing and examination of patent applications containing biological sequence information.