What is a “Sequence Listing XML” and when is it required?

This page is an FAQ based on guidance from the Manual of Patent Examining Procedure. It is provided as guidance, with links to the ground truth sources. This is information only: it is not legal advice.

A “Sequence Listing XML” is a file containing nucleotide and/or amino acid sequence information in XML format. It is required for applications filed on or after July 1, 2022, that contain disclosures of nucleotide and/or amino acid sequences as defined in 37 CFR 1.831(b).

As stated in MPEP 2414: “When an application filed on or after July 1, 2022, contains disclosures of nucleotides and/or amino acid sequences, a ‘Sequence Listing XML’ is required.”