What are the size limitations for ASCII plain text sequence listings?

This page is an FAQ based on guidance from the Manual of Patent Examining Procedure. It is provided as guidance, with links to the ground truth sources. This is information only: it is not legal advice.

The USPTO has specific size limitations for ASCII plain text sequence listings to ensure efficient processing and storage. According to MPEP 2422.03(a):

“The ASCII plain text file must not exceed 100 MB in size.“

This size limit is important for several reasons:

• It facilitates faster upload and download times for both applicants and examiners.
• It ensures compatibility with USPTO electronic filing systems.
• It helps manage storage requirements for patent application documents.

If a sequence listing exceeds 100 MB, applicants may need to consult with the USPTO for alternative submission methods or consider breaking the listing into multiple files if allowed by the specific application requirements.