How should sequence-related submissions be marked for the USPTO?

This page is an FAQ based on guidance from the Manual of Patent Examining Procedure. It is provided as guidance, with links to the ground truth sources. This is information only: it is not legal advice.

According to MPEP 2433, all sequence-related submissions to the USPTO should be marked “Box SEQUENCE.” This includes “all computer readable forms, read-only optical discs, fees, and papers accompanying them filed in the Office.” This marking facilitates administrative processing of all papers and read-only optical discs associated with sequence rule compliance.