How should circular nucleotide sequences be represented in patent applications?

According to MPEP 2412.05(b), circular nucleotide sequences in patent applications should be represented as follows:

• The applicant must choose the nucleotide in residue position number 1
• Numbering is continuous throughout the entire sequence in the 5′ to 3′ direction
• The last residue position number must equal the total number of nucleotides in the sequence

The MPEP states, “When nucleotide sequences are circular in configuration, applicant must choose the nucleotide in residue position number 1. Numbering is continuous throughout the entire sequence in the 5′ to 3′ direction, or in the direction that mimics the 5′ to 3′ direction.” This approach ensures consistency in representing circular nucleotide sequences in patent applications.

To learn more:

• circular nucleotide sequences
• sequence representation
• WIPO Standard ST.26
• numbering