How do the requirements for sequence listings differ between WIPO ST.25 and WIPO ST.26?

The requirements for sequence listings differ significantly between WIPO ST.25 and WIPO ST.26. WIPO ST.25 was the standard used for applications filed before July 1, 2022, while WIPO ST.26 applies to applications filed on or after that date. The MPEP notes: “See MPEP §§ 2412 – 2419 for guidance on WIPO ST.26 requirements for applications filed on or after July 1, 2022.” The main differences include changes in the format of sequence listings, the scope of sequences that must be included, and the way certain sequences are represented. Applicants and patent practitioners should carefully review the new requirements to ensure compliance with the appropriate standard based on their filing date.

Symbols and Format for Nucleotide/Amino Acid Sequences MPEP 2423 Informative
Symbols and Format for Sequence Data Must Conform to Requirements MPEP 2423 Required
Code for Nucleotide and Amino Acid Sequences Must Conform to Appendices A and C MPEP 2423 Required
Nucleotide and Amino Acid Sequence Codes Must Conform to Specified Standards MPEP 2423 Required
Modified Base or Amino Acid May Use Unmodified Code If Listed MPEP 2423 Permitted