How can I submit a replacement “Sequence Listing XML” file to the USPTO?
This page is an FAQ based on guidance from the Manual of Patent Examining Procedure. It is provided as guidance, with links to the ground truth sources. This is information only: it is not legal advice.
There are two methods for submitting a replacement “Sequence Listing XML” file to the USPTO:
- Via the USPTO patent electronic filing system (Patent Center)
- On a read-only optical disc, if the file size exceeds the upload limit of Patent Center
According to MPEP 2414.03: A compliant replacement “Sequence Listing XML” submitted as an XML file containing the entire “Sequence Listing XML,” including any additions, deletions, or replacements of sequence information, using either the USPTO Patent Electronic Filing System (currently, XML files can only be submitted via Patent Center) or a read-only optical disc that is mailed into the Office if the size of “Sequence Listing XML” file exceeds the upload limit of Patent Center
If submitting via optical disc, it must be labeled as “REPLACEMENT MM/DD/YYYY” with the creation date indicated.