What are the requirements for representing sequence variants in a “Sequence Listing XML”?
According to MPEP 2412.05(c), there are specific requirements for representing sequence variants in a “Sequence Listing XML”: Each primary sequence and its variants must be included separately and assigned unique sequence identifiers. Variants disclosed as a single sequence with enumerated alternative residues should be represented using the most restrictive ambiguity symbol. Variants disclosed only by…
Read MoreWhat is the proper representation for other types of amino acid variants?
The MPEP 2412.05(c) provides guidance for representing other types of amino acid variants: Feature Key: VARIANT Qualifier: note Use: Any type of variant for which VAR_SEQ is not applicable This representation is used for amino acid variants that do not result from alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. It ensures comprehensive…
Read MoreWhat symbols are used for amino acids in a sequence listing?
What symbols are used for amino acids in a sequence listing? In a sequence listing, amino acids are represented using specific symbols as defined by WIPO Standard ST.25. According to MPEP 2423.01: “The amino acids in a protein or peptide sequence must be represented using the three-letter abbreviation with the first letter as a capital.”…
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