What are the accepted symbols for modified nucleotides in sequence listings?
What are the accepted symbols for modified nucleotides in sequence listings?
According to MPEP 2412.05, modified nucleotides can be represented in sequence listings using specific symbols. The MPEP states:
“Modified nucleotides may be represented in the sequences as described in paragraph 3 of this section with the symbol “n,” and must be further described in the Feature section of the Sequence Listing.”
This means that any modified nucleotide should be represented by the symbol ‘n’ in the sequence itself. Additional details about the modification must be provided in the Feature section of the Sequence Listing to fully describe the nature of the modification.
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Topics:
MPEP 2400 - Biotechnology,
MPEP 2412.05 - Representation And Symbols For Nucleotide And/Or Amino Acid Sequences,
Patent Law,
Patent Procedure