What is the “Sequence Listing XML” and why is it important?
The “Sequence Listing XML” is a critical component of patent applications filed on or after July 1, 2022, that contain disclosures of nucleotide and/or amino acid sequences. It must comply with WIPO Standard ST.26 and include a sequence data part. As stated in MPEP 2413.01(g): “The sequence data part is the part of the ‘Sequence…
Read MoreHow should sequence variants be represented in a Sequence Listing XML?
Representation of sequence variants in a Sequence Listing XML is important for accurately describing genetic variations. According to MPEP 2413.01(g): Each primary sequence and its variants must be included in the sequence listing with their own sequence identifiers. Variants disclosed as a single sequence with enumerated alternative residues should be represented by a single sequence…
Read MoreHow should modified residues be represented in a Sequence Listing XML?
Representing modified residues correctly in a Sequence Listing XML is crucial for accurately describing non-standard amino acids or nucleotides. According to MPEP 2413.01(g): “For the ‘note’ qualifier, where the variant residue is a modified residue not set forth in Table 2, the complete unabbreviated name of the modified residue must be provided as the qualifier…
Read MoreHow should coding sequences (CDS) be represented in a Sequence Listing XML?
Coding sequences (CDS) in a Sequence Listing XML should be represented using the “CDS” feature key. According to MPEP 2413.01(g): “The ‘CDS’ feature key may be used to identify coding sequences, i.e., sequences of nucleotides which correspond to the sequence of amino acids in a protein and the stop codon. The location of the ‘CDS’…
Read MoreWhat are the mandatory qualifiers for the “source” feature key in a Sequence Listing XML?
The “source” feature key is mandatory for all nucleotide and amino acid sequences in a Sequence Listing XML, except for intentionally skipped sequences. According to MPEP 2413.01(g), there are two mandatory qualifiers for the “source” feature key: “organism” “mol_type” The “organism” qualifier must disclose the source or origin of the sequence, while the “mol_type” qualifier…
Read MoreWhat are the mandatory elements of the INSDSeq in a Sequence Listing XML?
The INSDSeq element in a Sequence Listing XML contains several mandatory dependent elements. According to MPEP 2413.01(g), these elements are: INSDSeq_length: Length of the sequence INSDSeq_moltype: Molecule type INSDSeq_division: Indication that a sequence is related to a patent application INSDSeq_feature-table: List of annotations of the sequence INSDSeq_sequence: The sequence itself These elements are crucial for…
Read MoreWhat is “free text” in a Sequence Listing XML and how should it be used?
“Free text” is a type of value format used for certain qualifiers in a Sequence Listing XML. According to MPEP 2413.01(g): “‘Free text’ is a type of value format for certain qualifiers presented in the form of a descriptive text phrase or other specified format.” Important guidelines for using free text include: Its use should…
Read MoreWhat is a feature table in a Sequence Listing XML and why is it important?
A feature table in a Sequence Listing XML is a crucial component that provides information about various regions within a particular sequence. As stated in MPEP 2413.01(g): “A feature table is required for every sequence, except for any intentionally skipped sequence, in which case it must not be included. The feature table is contained in…
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