How should unknown amino acids be represented in sequence listings?

How should unknown amino acids be represented in sequence listings?

The MPEP 2412.05 provides specific guidance on representing unknown amino acids in sequence listings:

“The symbol “Xaa” must be used to represent an unknown or other amino acid.”

This means that whenever an amino acid in a sequence is unknown or cannot be confidently identified, it should be represented by the symbol ‘Xaa’ in the sequence listing. This standardized approach ensures clarity and consistency in patent applications involving amino acid sequences with uncertain elements.

To learn more:

Topics: MPEP 2400 - Biotechnology, MPEP 2412.05 - Representation And Symbols For Nucleotide And/Or Amino Acid Sequences, Patent Law, Patent Procedure
Tags: Sequence Listings, Unknown Amino Acids, Xaa